DNA-protein interactions, structural studies of protein-nucleic acid interactions

Protein–nucleic acid interactions

MS04 Protein-protein and Protein-Nucleic acid interactions

24 European Crystallographic Meeting, ECM24, Marrakech, 2007 Page s132 Acta Cryst. (2007). A63, s132 MS04 P14 Preparation and crystallization of rat natural killer cell receptor NKR-P1B Ondrej Vanek, Petr Kolenko, Vladimir Kopecky, Jr., Jan Dohnalek, Karel Bezouska Department of Biochemistry, Faculty of Science, Charles University in Prague, Hlavova 2030,CZ-12840 Prague, Czech Republic. Institu...

Thermodynamic Database for Protein-Nucleic Acid Interactions

Protein-nucleic acid interaction plays an essential role in the regulation of gene expression. Structural and binding information provides insight into the mechanism of protein-nucleic acid recognition. Although there are structural databases for protein-nucleic acid complexes, there exists no database for protein-nucleic acid binding. Thus, we have decided to develop the Thermodynamic Database...

Discovering Domains Mediating Protein Interactions

Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...

Biophysics Electrostatic potential molecular surfaces ( nucleic acids / proteins / drug - nucleic acid interactions / protein - ligand interactions )

Color-coded computer graphics representations of the electrostatic potentials of trypsin, trypsin-inhibitor, prealbumin and its thyroxine complex, fragments of double-helical DNA, and a netropsin-DNA complex illustrate the electrostatic and topographic complementarity in macromolecule-ligand interactions. This approach is powerful in revealing intermolecular specificity and shows promise of hav...